Methadone, buprenorphine, or naltrexone: what's the difference?
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RH
RecoveryHome team Team
asked 2 days ago
There are three FDA-approved medications for opioid use disorder. How do they differ, and how do people choose?
RH
RecoveryHome team Team
answered 2 days ago · general information, not medical advice
All three are effective, and the right one depends on your history, health, and preferences.
Methadone
- Fully activates opioid receptors, which controls withdrawal and cravings
- Given at certified opioid treatment programs, usually with daily visits at first and take-home doses later
- Often a good fit for people with high tolerance or who haven't done well on other options
Buprenorphine (Suboxone is one brand)
- Partly activates opioid receptors, with a lower overdose risk
- Can be prescribed by many doctors and nurse practitioners in an office or by telehealth
- Starting it after fentanyl needs careful timing, so do it with a prescriber
Naltrexone (extended-release monthly injection)
- Blocks opioids instead of activating receptors
- Requires being fully off opioids, usually 7 to 10 days, before starting
- Can suit people who have already completed withdrawal
All three work best with ongoing care. Methadone and buprenorphine are linked to large reductions in overdose deaths.
Read more: Medication for opioid use disorder
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